The molecular pathology of hereditary breast cancer.

  title={The molecular pathology of hereditary breast cancer.},
  author={Jos{\'e} Palacios and Mar{\'i}a Jos{\'e} Robles-Fr{\'i}as and Mar{\'i}a Angeles Castilla and Mar{\'i}a {\'A}ngeles L{\'o}pez-Garc{\'i}a and Javier Ben{\'i}tez},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  volume={75 2},
Hereditary breast cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes differs from sporadic breast cancer and from non-BRCA1/2 familial breast carcinomas. Most BRCA1 carcinomas have the basal-like phenotype and are high-grade, highly proliferating, estrogen receptor-negative and HER2-negative breast carcinomas, characterized by the expression of basal markers such as basal keratins, P-cadherin and epidermal growth factor receptor. BRCA1 carcinomas frequently carry p53 mutations… CONTINUE READING
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Char - acterization of familial non - BRCA 1 / 2 breast tumors by loss of heterozygosity and immu - nophenotyping

  • RA Oldenburg, K Kroeze-Jansema, +10 authors P Devilee
  • Clin Cancer Res
  • 2006

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