The molecular origins of specificity in the assembly of a multienzyme complex.

@article{Frank2005TheMO,
  title={The molecular origins of specificity in the assembly of a multienzyme complex.},
  author={Ren{\'e} Frank and J. Venkatesh Pratap and Xue Yuan Pei and Richard N. Perham and Ben F Luisi},
  journal={Structure},
  year={2005},
  volume={13 8},
  pages={1119-30}
}
The pyruvate dehydrogenase (PDH) multienzyme complex is central to oxidative metabolism. We present the first crystal structure of a complex between pyruvate decarboxylase (E1) and the peripheral subunit binding domain (PSBD) of the dihydrolipoyl acetyltransferase (E2). The interface is dominated by a "charge zipper" of networked salt bridges. Remarkably, the PSBD uses essentially the same zipper to alternately recognize the dihydrolipoyl dehydrogenase (E3) component of the PDH assembly. The… CONTINUE READING

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