The molecular origin of the MMR-dependent apoptosis pathway from dynamics analysis of MutSα-DNA complexes.

Abstract

The cellular response to DNA damage signaling by mismatch-repair (MMR) proteins is incompletely understood. It is generally accepted that MMR-dependent apoptosis pathway in response to DNA damage detection is independent of MMR's DNA repair function. In this study, we investigate correlated motions in response to the binding of mismatched and platinum cross… (More)
DOI: 10.1080/07391102.2012.680034

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@article{Negureanu2012TheMO, title={The molecular origin of the MMR-dependent apoptosis pathway from dynamics analysis of MutSα-DNA complexes.}, author={Lacramioara Negureanu and Freddie R. Salsbury}, journal={Journal of biomolecular structure & dynamics}, year={2012}, volume={30 3}, pages={347-61} }