The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.

@article{Kishimoto1997TheMN,
  title={The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.},
  author={Yasuyuki Kishimoto and Young Bok Lee and Leonard I. Zon and Matthias Hammerschmidt and Stefan Schulte-Merker},
  journal={Development},
  year={1997},
  volume={124 22},
  pages={
          4457-66
        }
}
Early dorsoventral pattern formation in vertebrate embryos is regulated by opposing activities of ventralizing bone morphogenetic proteins (BMPs) and dorsal-specific BMP antagonists such as Chordin, Noggin and Follistatin. Specific defects in early dorsoventral patterning have been recently found in a number of zebrafish mutants, which exhibit either a ventralized or dorsalized phenotype. One of these, the ventralized mutant chordino (originally called dino) is caused by a mutation in the… CONTINUE READING

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