The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver.

@article{Matsunaga2008TheMM,
  title={The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver.},
  author={Naoya Matsunaga and Misaki Ikeda and Takako Takiguchi and Satoru Koyanagi and Shigehiro Ohdo},
  journal={Hepatology},
  year={2008},
  volume={48 1},
  pages={240-51}
}
UNLABELLED Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24-hour periodicity in its activity. In the present study, we investigated whether hepatic nuclear factor-1alpha (HNF-1alpha) and clock genes with a striking 24-hour rhythm in mouse liver contributed to the 24-hour regulation of CYP2E1 expression. The results… CONTINUE READING