The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.

@article{Shimada2004TheMM,
  title={The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.},
  author={Keiji Shimada and Mitsutoshi Nakamura and Eiwa Ishida and Munehiro Kishi and Syuchi Matsuyoshi and Noboru Konishi},
  journal={Molecular carcinogenesis},
  year={2004},
  volume={39 1},
  pages={
          1-9
        }
}
It is widely known that death receptor Fas-dependent apoptotic signals are associated with development of prostate cancer, but the key pathways involved in sensitivity to the apoptosis remain unclear. Here we investigated the molecular mechanism by which 2-methoxyestradiol (2-ME) effectively sensitizes a human prostate cancer cell line, PC3, to Fas-mediated apoptosis. 2-ME significantly inhibited nuclear factor-kappaB (NF-kappaB) activation and downregulated Fas-associated death domain (FADD… CONTINUE READING
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