The molecular mechanism of resistance to methotrexate in mouse methotrexate-resistant cells by cancer drug resistance and metabolism SuperArray.

@article{Zhang2006TheMM,
  title={The molecular mechanism of resistance to methotrexate in mouse methotrexate-resistant cells by cancer drug resistance and metabolism SuperArray.},
  author={Chun-yu Zhang and Yuan-xi Feng and Yang Yu and Wenjing Sun and Jing Bai and Feng Chen and Song-bin Fu},
  journal={Basic & clinical pharmacology & toxicology},
  year={2006},
  volume={99 2},
  pages={141-5}
}
Drug resistance is often a limiting factor in successful chemotherapy. Understanding of the molecular mechanism of resistance to methotrexate is important for optimal use as well as for the development of new drugs. Using standard cytogenetic techniques, double minutes (DMs) were detected in mouse methotrexate-resistant cell lines inducted in vitro in this study. Moreover, functional SuperArray, determining the regulation of gene expression corresponding to 96 genes involved in the metabolism… CONTINUE READING