The molecular mechanism of autophagy.

  title={The molecular mechanism of autophagy.},
  author={C Wang and Daniel J Klionsky},
  journal={Molecular medicine},
  volume={9 3-4},
Autophagy is a conserved trafficking pathway that is highly regulated by environmental conditions. During autophagy, portions of cytoplasm are sequestered into a double-membrane autophagosome and delivered to a degradative organelle, the vacuole in yeast and the lysosome in mammalian cells, for breakdown and recycling. Autophagy is induced under starvation conditions and in mammalian cells is also invoked in response to specific hormones. In yeast, under nutrient-rich conditions, a constitutive… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 186 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…