The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.

@article{Frith2001TheMM,
  title={The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.},
  author={Julie C Frith and Jukka M{\"o}nkk{\"o}nen and Seppo Auriola and Hannu M{\"o}nkk{\"o}nen and Michael J Rogers},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 9},
  pages={2201-10}
}
OBJECTIVE The primary aims of this study were to determine whether clodronate and liposome-encapsulated clodronate are metabolized to adenosine 5'-(beta,gamma-dichloromethylene) triphosphate (AppCCl2p) by osteoclasts and macrophages in vivo, and to determine whether intracellular accumulation of this metabolite accounts for the antiresorptive and antimacrophage effects of clodronate. To compare the mechanism of action of clodronate and alendronate, effects on protein prenylation in osteoclasts… CONTINUE READING