The molecular mechanism by which adrenalin inhibits glycogen synthesis.

  title={The molecular mechanism by which adrenalin inhibits glycogen synthesis.},
  author={Sara Nakielny and David G Campbell and Philip J. Cohen},
  journal={European journal of biochemistry},
  volume={199 3},
Improved methodology was used to establish that the phosphorylation of a serine located 10 residues from the N-terminus of glycogen synthase (N10) increases from 0.12 mol.mol-1 to 0.54 mol.mol-1 in vivo in response to adrenalin. The only 'N10 kinase' detected in muscle extracts was casein kinase-1 (CK1), although its activity was unaffected by injection of adrenalin in vivo or by incubation with cyclic-AMP-dependent protein kinase and MgATP in vitro. Prior phosphorylation of the serine residue… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Tau-tubulin kinase

Front. Mol. Neurosci. • 2014

Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2003

Similar Papers

Loading similar papers…