The molecular mechanism by which adrenalin inhibits glycogen synthesis.

@article{Nakielny1991TheMM,
  title={The molecular mechanism by which adrenalin inhibits glycogen synthesis.},
  author={Sara Nakielny and David G Campbell and Philip J. Cohen},
  journal={European journal of biochemistry},
  year={1991},
  volume={199 3},
  pages={713-22}
}
Improved methodology was used to establish that the phosphorylation of a serine located 10 residues from the N-terminus of glycogen synthase (N10) increases from 0.12 mol.mol-1 to 0.54 mol.mol-1 in vivo in response to adrenalin. The only 'N10 kinase' detected in muscle extracts was casein kinase-1 (CK1), although its activity was unaffected by injection of adrenalin in vivo or by incubation with cyclic-AMP-dependent protein kinase and MgATP in vitro. Prior phosphorylation of the serine residue… CONTINUE READING

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