The molecular machinery of synaptic vesicle exocytosis

  title={The molecular machinery of synaptic vesicle exocytosis},
  author={Liyi Li and L.-S. Chin},
  journal={Cellular and Molecular Life Sciences CMLS},
At the synapse, neurotransmitters are released via Ca2+-triggered exocytotic fusion of synaptic vesicles with the presynaptic plasma membrane. Synaptic vesicle exocytosis seems to share many basic principles and homologous proteins with other membrane fusion events. Conserved components of the general fusion machinery that participate in synaptic vesicle exocytosis include soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), ATPase N-ethylmaleimide-sensitive factor… CONTINUE READING
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