The molecular machinery of Keilin's respiratory chain.

@article{Rich2003TheMM,
  title={The molecular machinery of Keilin's respiratory chain.},
  author={Peter R Rich},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 6},
  pages={
          1095-105
        }
}
  • P. Rich
  • Published 2003
  • Chemistry, Medicine
  • Biochemical Society transactions
Keilin's classic paper of 1925 [Keilin (1925) Proc. R. Soc. London Ser. B 100, 129-151], achieved with simple, but elegant, techniques, describes the cytochrome components of the respiratory chain and their roles in intracellular respiration and oxygen consumption. Since that time, a tremendous amount of work has clarified the intricate details of the prosthetic groups, cofactors and proteins that comprise the respiratory chain and associated machinery for ATP synthesis. The work has culminated… Expand
Megacomplex organization of the oxidative phosphorylation system by structural analysis of respiratory supercomplexes from potato.
TLDR
A consistent model of the respiratory string, composed of repeating I( 2)+III(2)+IV(2) units, which is in agreement with dimensions observed in former freeze-fracture electron microscopy data is proposed. Expand
The mitochondrial respiratory chain.
TLDR
The structures and mechanisms of the major components of mammalian mitochondrial respiratory chains are reviewed, with particular emphasis on the four protein complexes and their cofactors that catalyse the electron transfer pathway between oxidation of NADH and succinate and the reduction of oxygen to water. Expand
as Terminal Electron Acceptor : From TCA Cycle to Cytochrome Oxidase V 9 . 2 . Iron-Based Oxygenases
Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms ofExpand
On the power per mitochondrion and the number of associated active ATP synthases
TLDR
A semi-quantitative bookkeeping whereby, in one stroke, a formula is proposed that yields the rate of heat production in a typical mitochondrion and a formula for estimating the number of “active” ATP synthase molecules per mitochondrions is proposed. Expand
The efficiency and plasticity of mitochondrial energy transduction.
  • M. Brand
  • Biology, Medicine
  • Biochemical Society transactions
  • 2005
TLDR
UCP1 (uncoupling protein 1) is used in specialized tissues to uncouple oxidative phosphorylation, causing adaptive thermogenesis and UCPs may also integrate inputs from different fuels in pancreatic beta-cells and modulate insulin secretion, creating exciting potential targets for treatment of obesity, cachexia, aging and diabetes. Expand
Structure, function and mechanism of the alternative oxidases
TLDR
Colletochlorin B, an analogue of ascofuranone, was synthesised and its inhibitory efficacy against AOX examined, demonstrating that removal of the problematic furanone ring does not reduce inhibitor efficacy to a large degree. Expand
The timing of proton migration in membrane-reconstituted cytochrome c oxidase.
TLDR
The results indicate that during CcO turnover internal electron transfer to the catalytic site is controlled by the release of the pumped proton, which suggests a mechanism by which CcC orchestrates a tight coupling between electron transfer and proton translocation. Expand
Low-molecular-weight oxidants involved in disulfide bond formation.
  • L. Ruddock
  • Chemistry, Medicine
  • Antioxidants & redox signaling
  • 2012
TLDR
This review critically examines the potential low molecular oxidants that maybe involved in the catalyzed or noncatalyzed formation of disulfide bonds, with an emphasis on the mammalian endoplasmic reticulum, via an examination of their thermodynamics, kinetics, and availability and gives pointers to help guide future experimental work. Expand
Redox-driven membrane-bound proton pumps.
  • P. Brzezinski
  • Chemistry, Medicine
  • Trends in biochemical sciences
  • 2004
TLDR
This work has shown that the mechanism of proton pumping has not been determined in any proton pump driven by reduction–oxidation reactions, and has brought us to its core and closer to its solution. Expand
Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation.
TLDR
The results categorically demonstrate that electron transport and proton circuitry in this model bacterium are spatially delocalized over the cell membrane, in stark contrast to mitochondrial bioenergetic supercomplexes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-3 OF 3 REFERENCES
Molecular Cell Biology
Molecular cell biology , Molecular cell biology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی