The molecular machinery of Keilin's respiratory chain.

@article{Rich2003TheMM,
  title={The molecular machinery of Keilin's respiratory chain.},
  author={Peter R. Rich},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 6},
  pages={
          1095-105
        }
}
  • P. Rich
  • Published 1 December 2003
  • Biology
  • Biochemical Society transactions
Keilin's classic paper of 1925 [Keilin (1925) Proc. R. Soc. London Ser. B 100, 129-151], achieved with simple, but elegant, techniques, describes the cytochrome components of the respiratory chain and their roles in intracellular respiration and oxygen consumption. Since that time, a tremendous amount of work has clarified the intricate details of the prosthetic groups, cofactors and proteins that comprise the respiratory chain and associated machinery for ATP synthesis. The work has culminated… 

Figures from this paper

as Terminal Electron Acceptor : From TCA Cycle to Cytochrome Oxidase V 9 . 2 . Iron-Based Oxygenases
TLDR
The underlying chemical logic is provided to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfer (IPP), glucosyl transferred (UDP-glucose, and electron and ADPribosyl transfers) to drive metabolic transformations in and across most primary pathways.
The mitochondrial respiratory chain.
TLDR
The structures and mechanisms of the major components of mammalian mitochondrial respiratory chains are reviewed, with particular emphasis on the four protein complexes and their cofactors that catalyse the electron transfer pathway between oxidation of NADH and succinate and the reduction of oxygen to water.
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.
TLDR
The underlying chemical logic is provided to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfer (IPP), glucosyl transferred (UDP-glucose), and electron and ADP-ribosyl transfers to drive metabolic transformations in and across most primary pathways.
On the power per mitochondrion and the number of associated active ATP synthases
TLDR
A semi-quantitative bookkeeping whereby, in one stroke, a formula is proposed that yields the rate of heat production in a typical mitochondrion and a formula for estimating the number of “active” ATP synthase molecules per mitochondrions is proposed.
The efficiency and plasticity of mitochondrial energy transduction.
  • M. Brand
  • Biology
    Biochemical Society transactions
  • 2005
TLDR
UCP1 (uncoupling protein 1) is used in specialized tissues to uncouple oxidative phosphorylation, causing adaptive thermogenesis and UCPs may also integrate inputs from different fuels in pancreatic beta-cells and modulate insulin secretion, creating exciting potential targets for treatment of obesity, cachexia, aging and diabetes.
Structure, function and mechanism of the alternative oxidases
TLDR
Colletochlorin B, an analogue of ascofuranone, was synthesised and its inhibitory efficacy against AOX examined, demonstrating that removal of the problematic furanone ring does not reduce inhibitor efficacy to a large degree.
The timing of proton migration in membrane-reconstituted cytochrome c oxidase.
TLDR
The results indicate that during CcO turnover internal electron transfer to the catalytic site is controlled by the release of the pumped proton, which suggests a mechanism by which CcC orchestrates a tight coupling between electron transfer and proton translocation.
Low-molecular-weight oxidants involved in disulfide bond formation.
  • L. Ruddock
  • Biology
    Antioxidants & redox signaling
  • 2012
TLDR
This review critically examines the potential low molecular oxidants that maybe involved in the catalyzed or noncatalyzed formation of disulfide bonds, with an emphasis on the mammalian endoplasmic reticulum, via an examination of their thermodynamics, kinetics, and availability and gives pointers to help guide future experimental work.
Redox-driven membrane-bound proton pumps.
  • P. Brzezinski
  • Chemistry, Physics
    Trends in biochemical sciences
  • 2004
...
...

References

SHOWING 1-3 OF 3 REFERENCES
Molecular Cell Biology
Molecular cell biology , Molecular cell biology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی