The molecular machinery for cAMP-dependent immunomodulation in T-cells.

@article{Taskn2006TheMM,
  title={The molecular machinery for cAMP-dependent immunomodulation in T-cells.},
  author={Kjetil Task{\'e}n and Anne Jorunn Stokka},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 4},
  pages={476-9}
}
cAMP inhibits Src-family kinase signalling by PKA (protein kinase A)-mediated phosphorylation and activation of Csk (C-terminal Src kinase). The PKA type I-Csk pathway is assembled and localized in membrane microdomains (lipid rafts) and regulates immune responses activated through the TCR (T-cell receptor). PKA type I is targeted to the TCR-CD3 complex during T-cell activation via an AKAP (A-kinase-anchoring protein) that serves as a scaffold for the cAMP-PKA/Csk pathway in lipid rafts of the… CONTINUE READING
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…