The molecular links between TDP-43 dysfunction and neurodegeneration.

  title={The molecular links between TDP-43 dysfunction and neurodegeneration.},
  author={Emanuele Buratti and Francisco E. Baralle},
  journal={Advances in genetics},
TDP-43 nuclear protein is involved in several major neurodegenerative diseases that include frontotemporal lobar degeneration with ubiquitin (FTLD-U) bodies and amyotrophic lateral sclerosis (ALS). As a consequence, the role played by this protein in both normal and diseased cellular metabolism has come under very close scrutiny. In the neuronal tissues of affected individuals TDP-43 undergoes aberrant localization to the cytoplasm to form insoluble aggregates. Furthermore, it is subject to… CONTINUE READING