The molecular genetics of embryonic pattern formation in Drosophila

  title={The molecular genetics of embryonic pattern formation in Drosophila},
  author={Philip W. Ingham},
  • P. Ingham
  • Published 1 September 1988
  • Biology
  • Nature
Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactions between transcriptional regulators', the second occurs after cellularization and depends on communication between cells. These processes may be conserved in a wide range of… 

Pattern formation by transcriptional cascades in the Drosophila embryo

This work provides first insight into the molecular mechanisms by which long-range positional information in the egg causes a series of localized zygotic transcription factor gradients to position development fate along the axes of the blastoderm embryo.

The initiation of pair-rule stripes in the Drosophila blastoderm.

Genetic and Molecular Analysis of Pattern Formation Processes in Drosophila

A detailed understanding of the processes controlling Drosophila development has become possible by a systematic genetic analysis of mutations leading to pattern defects during embryogenesis. It was

Musterbildung bei Drosophila

: Drosophila proved an excellent system to study molecular processes in establishing the body pattern of an embryo. Genes which are active during oogenesis provide localized cues which regulate a

Early Embryonic Development of Animals

  • W. Hennig
  • Biology
    Results and Problems in Cell Differentiation
  • 1992
Analysis of early development in the Zebrafish Embryo and Genomic Imprinting in Mammals shows the importance of knowing the carrier and removal status of canine coronavirus to understand the origin of infectious disease.

Drosophila blastoderm patterning.

Developmental evolution: insights from studies of insect segmentation.

Comparisons to other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events in Drosophila melanogaster.

Transcriptional cascades in Drosophila.

Homeotic genes of Drosophila.

  • G. Morata
  • Biology
    Current opinion in genetics & development
  • 1993



Genetics of early neurogenesis in Drosophila melanogaster.

Cells of the neurogenic ectoderm of insects must decide between two alternative fates, the neurogenic and the epidermogenic. In the last few years several genes have been identified in Drosophila

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory

Determination of anteroposterior polarity in Drosophila.

The principles of pattern formation in embryogenesis can be studied in Drosophila by means of a powerful combination of genetic and transplantation experiments. The segmented pattern of the

Mutations affecting segment number and polarity in Drosophila

The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.

A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease

The molecular cloning of the gene and analysis of a complementary DNA sequence suggest that the gene encodes a serine protease which is structurally similar to proteases involved in blood clotting, peptide processing, and complement fixation pathways.

Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos

The spatial and temporal characteristics of Kr gene expression during early embryo development, the localization of cytoplasmic Kr+ activity and its spatial requirement for normal segmentation are elucidated.

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

The organization of the anterior pattern in the Drosophila embryo is mediated by the maternal effect gene bicoid and the mRNA is localized at the anterior tip of oocyte and early embryo until the cellular blastoderm stage.

The molecular basis for metameric pattern in the Drosophila embryo.

The metameric organization of the Drosophila embryo is generated in the first 5 h after fertilization. An initially rather simple pattern provides the foundation for subsequent development and