The molecular evolution of genes and proteins: a tale of two serines

@article{Brenner1988TheME,
  title={The molecular evolution of genes and proteins: a tale of two serines},
  author={S. Brenner},
  journal={Nature},
  year={1988},
  volume={334},
  pages={528-530}
}
The advent of techniques for cloning and rapidly sequencing DNA has produced an explosive increase of sequence information for nucleic acids and their inferred proteins. Careful study of this large store of data might give us new insights into the relations between the linear sequences of genes and their functions embodied in the three-dimensional structure of proteins, and also illuminate the origin and evolution of the structural complexity of present-day proteins. Here I argue from such a… CONTINUE READING