The molecular epidemiology of p53 gene mutations in human breast cancer.

@article{Hartmann1997TheME,
  title={The molecular epidemiology of p53 gene mutations in human breast cancer.},
  author={Arndt Hartmann and Hagen J. Blaszyk and John S. Kovach and S. S. Sommer},
  journal={Trends in genetics : TIG},
  year={1997},
  volume={13 1},
  pages={27-33}
}
The P53 tumor-suppressor gene is an advantageous tool for analyzing the molecular epidemiology of cancer. We describe the utility of the P53 gene as a 'mutagen test' and a prognostic indicator in breast cancer. Aspects of study design and methodology are discussed. Two major conclusions emerge: (1) there is an extraordinary diversity of mutational patterns among cohorts, hinting that the unique biology of mammary cells results in exposure to high doses of a diversity of ingested lipophilic… CONTINUE READING

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