The molecular effects of acrolein.

@article{Kehrer2000TheME,
  title={The molecular effects of acrolein.},
  author={James P. Kehrer and Shuvranshu Shekhar Biswal},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={57 1},
  pages={
          6-15
        }
}
Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke. In addition, as a metabolite of cyclophosphamide, acrolein is a major factor in the toxicity and perhaps the therapeutic activity of this important anticancer agent. The exposures to acrolein that are attained in vivo in most situations are quite low and the effects may differ from those seen at acutely toxic doses. At low… CONTINUE READING

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