The molecular effects of acrolein.

@article{Kehrer2000TheME,
  title={The molecular effects of acrolein.},
  author={James P. Kehrer and Shuvranshu Shekhar Biswal},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={57 1},
  pages={
          6-15
        }
}
Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke. In addition, as a metabolite of cyclophosphamide, acrolein is a major factor in the toxicity and perhaps the therapeutic activity of this important anticancer agent. The exposures to acrolein that are attained in vivo in most situations are quite low and the effects may differ from those seen at acutely toxic doses. At low… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 103 REFERENCES

Oxidative stress and gene regulation.

  • Free radical biology & medicine
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Current status of acrolein as a lipid peroxidation product

K. Uchida
  • Trends Cardiovasc. Med
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Biochemical and molecular mechanisms regulating apoptosis

  • Molecular and Cellular Biochemistry
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Air pollution

D. L. Costa, M. O. Amdur
  • Casarett & Doull ’ s Toxicology
  • 1996
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Glutathione content and growth in A549 human lung carcinoma cells.

  • Experimental cell research
  • 1990
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

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