The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua.

@article{Rydn2010TheMC,
  title={The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua.},
  author={Anna-Margareta Ryd{\'e}n and Carolien P. Ruyter-Spira and Wim J Quax and Hiroyuki Osada and Toshiya Muranaka and Oliver Kayser and Harro Bouwmeester},
  journal={Planta medica},
  year={2010},
  volume={76 15},
  pages={1778-83}
}
A key point in the biosynthesis of the antimalarial drug artemisinin is the formation of dihydroartemisinic aldehyde which represents the key difference between chemotype specific pathways. This key intermediate is the substrate for several competing enzymes, some of which increase the metabolic flux towards artemisinin, and some of which--as we show in the present study--may have a negative impact on artemisinin production. In an effort to understand the biosynthetic network of artemisinin… CONTINUE READING

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