The molecular classification of the clinical manifestations of Crohn's disease.

  title={The molecular classification of the clinical manifestations of Crohn's disease.},
  author={Tariq Ahmad and Alessandro Armuzzi and Mike Bunce and Kim Mulcahy-Hawes and Sara E F Marshall and Timothy R. Orchard and Jonathan Crawshaw and Oliver Large and Arjuna Priyadarsin de Silva and J. T. E. Cook and Martin C. N. M. Barnardo and Sue Cullen and Ken Ian Welsh and Derek P. Jewell},
  volume={122 4},
BACKGROUND & AIMS Crohn's disease is a common inflammatory disorder of the gut characterized by variation in both location and behavior. Chromosome 16 and the HLA region on chromosome 6 have been implicated in susceptibility to disease. Mutations in the NOD2/CARD15 gene, recently identified on chromosome 16, have been associated with disease overall but are found in only 25% of patients. No data regarding their contribution to specific disease subtypes exist. Here we report a detailed genotype… CONTINUE READING
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