The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.

Abstract

The interferon-induced double-stranded RNA-activated protein kinase, PKR, likely contributes to both the antiviral and the antiproliferative effects of interferon. We previously found that influenza virus avoids the translational inhibitory effects of activated PKR by activating a cellular inhibitory protein, termed P58IPK, based on its Mr of 58,000. P58IPK… (More)

Topics

Cite this paper

@article{Melville1997TheMC, title={The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.}, author={M. W. Melville and W. J. Hansen and Becky Freeman and Will Welch and Michael G. Katze}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 1}, pages={97-102} }