The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.

@article{Wiest1995TheMC,
  title={The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.},
  author={David L Wiest and Wilson H. Burgess and D C McKean and Kelly P. Kearse and Alfred Singer},
  journal={The EMBO journal},
  year={1995},
  volume={14 14},
  pages={3425-33}
}
Immature thymocytes express clonotype-independent CD3 complexes that, when engaged by anti-CD3 antibodies, can signal CD4-CD8- thymocytes to differentiate into CD4+CD8+ cells. Clonotype-independent CD3 complexes consist of CD3 components associated with an unknown 90 kDa surface protein. We now report the surprising finding that this 90 kDa surface protein is the molecular chaperone calnexin, an integral membrane protein previously thought to reside only in the endoplasmic reticulum (ER). We… CONTINUE READING

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