The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64.

@article{Qbadou2006TheMC,
  title={The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64.},
  author={Soumya Qbadou and Thomas Becker and Oliver Mirus and Ivo Tews and J{\"u}rgen Soll and Enrico Schleiff},
  journal={The EMBO journal},
  year={2006},
  volume={25 9},
  pages={
          1836-47
        }
}
Precursor protein targeting toward organellar surfaces is assisted by different cytosolic chaperones. We demonstrate that the chloroplast protein translocon subunit Toc64 is the docking site for Hsp90 affiliated preproteins. Thereby, Hsp90 is recognised by the clamp type TPR domain of Toc64. The subsequent transfer of the preprotein from Toc64 to the major receptor of the Toc complex, namely Toc34, is affinity driven and nucleotide dependent. We propose that Toc64 acts as an initial docking… CONTINUE READING
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