The molecular biology of prion propagation.

@article{Clarke2001TheMB,
  title={The molecular biology of prion propagation.},
  author={Adam R Clarke and Graham Stuart Jackson and J. A. Collinge},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2001},
  volume={356 1406},
  pages={
          185-95
        }
}
Prion diseases such as Creutzfeldt-Jakob disease (CJD) in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals are associated with the accumulation in affected brains of a conformational isomer (PrP(Sc)) of host-derived prion protein (PrP(C)). According to the protein-only hypothesis, PrP(Sc) is the principal or sole component of transmissible prions. The conformational change known to be central to prion propagation, from a predominantly alpha-helical fold to one… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Similar Papers

Loading similar papers…