The molecular biology of human herpesvirus-6 latency and telomere integration.

@article{Arbuckle2011TheMB,
  title={The molecular biology of human herpesvirus-6 latency and telomere integration.},
  author={Jesse H Arbuckle and Peter G. Medveczky},
  journal={Microbes and infection},
  year={2011},
  volume={13 8-9},
  pages={731-41}
}
The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host. 

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