The molecular biology of Borrelia.

  title={The molecular biology of Borrelia.},
  author={Alan G Barbour},
  journal={Reviews of infectious diseases},
  volume={11 Suppl 6},
Borrelia burgdorferi, the cause of Lyme disease, has two major outer-membrane proteins, OspA and OspB, which act as surface antigens. A 49-kilobase linear plasmid contains the genes that encode for these surface proteins. Direct examination of denatured plasmid molecules has revealed single-stranded circles with a circumference of approximately 100 kilobases (about twice the length of the linear duplex molecule), a finding that indicates the plasmid strands have covalently closed ends. This… CONTINUE READING

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