The molecular basis of water transport in the brain

  title={The molecular basis of water transport in the brain},
  author={Mahmood Amiry-Moghaddam and Ole P. Ottersen},
  journal={Nature Reviews Neuroscience},
Brain function is inextricably coupled to water homeostasis. The fact that most of the volume between neurons is occupied by glial cells, leaving only a narrow extracellular space, represents an important challenge, as even small extracellular volume changes will affect ion concentrations and therefore neuronal excitability. Further, the ionic transmembrane shifts that are required to maintain ion homeostasis during neuronal activity must be accompanied by water. It follows that the mechanisms… CONTINUE READING
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An α-syntrophin-dependent pool of Aqp4 in astroglial end-feet confers bidirectional water flow between blood and brain

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