The molecular basis of water transport in the brain

@article{AmiryMoghaddam2003TheMB,
  title={The molecular basis of water transport in the brain},
  author={Mahmood Amiry-Moghaddam and Ole Petter Ottersen},
  journal={Nature Reviews Neuroscience},
  year={2003},
  volume={4},
  pages={991-1001}
}
Brain function is inextricably coupled to water homeostasis. The fact that most of the volume between neurons is occupied by glial cells, leaving only a narrow extracellular space, represents an important challenge, as even small extracellular volume changes will affect ion concentrations and therefore neuronal excitability. Further, the ionic transmembrane shifts that are required to maintain ion homeostasis during neuronal activity must be accompanied by water. It follows that the mechanisms… 
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  • 2004
bstract—The mammalian CNS is separated from the blood y tight junctions, collectively termed the blood–brain barrier BBB). This imposes unique features of solvent and water ovement into and out of
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Experimental evidence is critically discussed about the molecular and functional interplay of aquaporin 4, the major Aquaporin protein in astroglial cells, with potassium and gap-junctional channels that are involved in extracellular potassium buffering and the interactions of aquarovin 4 with chloride and calcium channels regulating cell volume homeostasis.
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TLDR
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TLDR
A review will be provided of the physiological roles of AQP4 in brain and of the growing list of data that emphasize the polarized nature of astrocytes.
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TLDR
Investigation of AQP expression in the canine and feline brain should be pursued so that clinically relevant comparisons between findings in mice, rats, and people and animal patients can be made.
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