The molecular basis of two contrasting metabolic mechanisms of insecticide resistance.

@article{Hemingway2000TheMB,
  title={The molecular basis of two contrasting metabolic mechanisms of insecticide resistance.},
  author={Janet Hemingway},
  journal={Insect biochemistry and molecular biology},
  year={2000},
  volume={30 11},
  pages={1009-15}
}
The esterase-based insecticide resistance mechanisms characterised to date predominantly involve elevation of activity through gene amplification allowing increased levels of insecticide sequestration, or point mutations within the esterase structural genes which change their substrate specificity. The amplified esterases are subject to various types of gene regulation in different insect species. In contrast, elevation of glutathione S-transferase activity involves upregulation of multiple… CONTINUE READING

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Quantitative analysis of gene amplication in insecticide resistant Culex mosquitoes

  • M. G. Paton, E. Giakoumaki, N. Roberts, J. Hemingway
  • Biochemical Journal
  • 2000
Highly Influential
3 Excerpts

Positional cloning of DDT resistance genes fromAnopheles gambiae

  • H. Ranson, J. Hemingway, F. H. Collins
  • 1999
Highly Influential
3 Excerpts

Two different amino acid substitutions in the ali-esterase, E3, confer alternative types of organophosphorus insecticide resistance in the sheep blowfly

  • P. M. Campbell, R. D. Newcomb, R. J. Russell, J. G. Oakeshott
  • 1998
Highly Influential
4 Excerpts

1009–1015 athione-dependent reactions in susceptible and resistant houseflies

  • J. Hemingway
  • Insect Biochemistry and Molecular Biology
  • 2000
2 Excerpts

Molecular characterisation of the amplified carboxylesterase gene associated with organophosphorus insecticide resistance in the brown planthopper

  • G.J, J. Hemingway
  • Nilaparvata lugensStal. Ins. Biochem. Mol. Biol
  • 2000

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