The molecular basis of two contrasting metabolic mechanisms of insecticide resistance.

  title={The molecular basis of two contrasting metabolic mechanisms of insecticide resistance.},
  author={Janet Hemingway},
  journal={Insect biochemistry and molecular biology},
  volume={30 11},
The esterase-based insecticide resistance mechanisms characterised to date predominantly involve elevation of activity through gene amplification allowing increased levels of insecticide sequestration, or point mutations within the esterase structural genes which change their substrate specificity. The amplified esterases are subject to various types of gene regulation in different insect species. In contrast, elevation of glutathione S-transferase activity involves upregulation of multiple… CONTINUE READING

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