The molecular basis of thrombolysis and its clinical application in stroke.

@article{Murray2010TheMB,
  title={The molecular basis of thrombolysis and its clinical application in stroke.},
  author={Veronica Murray and Bo Norrving and Peter Ag Sandercock and Andreas Ter{\'e}nt and Joanna M. Wardlaw and Per Wester},
  journal={Journal of internal medicine},
  year={2010},
  volume={267 2},
  pages={191-208}
}
The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fibrin and lyses the clot, which then allows reperfusion of the ischaemic brain. Thrombolytic agents… CONTINUE READING