The molecular basis of the structure and function of the 5-HT 3 receptor: a model ligand-gated ion channel (Review)

@article{Reeves2002TheMB,
  title={The molecular basis of the structure and function of the 5-HT 3 receptor: a model ligand-gated ion channel (Review)},
  author={David C. Reeves and Sarah C. R. Lummis},
  journal={Molecular Membrane Biology},
  year={2002},
  volume={19},
  pages={11 - 26}
}
The ligand-gated ion channel superfamily of neurotransmitter receptors are proteins responsible for rapid transmission of nerve impulses at the synapse and have, therefore, been the subject of intensive research for many years. The cys-loop family, of which the 5-HT3 receptor is a member, includes the nicotinic acetylcholine receptor, the GABAA receptor and the glycine receptor. A diverse range of endogenous and artificial ligands activate these receptors, but, nevertheless, the family shares… 
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The analysis of the three-dimensional model allows one to distinguish among amino acids that exert key roles in ligand interactions, subunit architecture, receptor assembly and receptor dynamics, and alternative roles with respect to the ones hypothesized by experimentalists are assigned.
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TLDR
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TLDR
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TLDR
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