The molecular basis of the human serum paraoxonase activity polymorphism

  title={The molecular basis of the human serum paraoxonase activity polymorphism},
  author={R. Humbert and David A. Adler and Christine M Disteche and Christopher Hassett and Curtis John Omiecinski and Clement E. Furlong},
  journal={Nature Genetics},
The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. A genetic polymorphism of paraoxonase (PON) activity which determines high versus low paraoxon hydrolysis in human populations, may determine sensitivity to parathion poisoning. We demonstrate that arginine at position 192 specifies high activity PON whereas a glutamine specifies the low activity variant. Allele–specific probes or restriction enzyme analysis of amplified DNA allow for the… CONTINUE READING
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