The molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum

@inproceedings{Langenhove2012TheMB,
  title={The molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum},
  author={Tim van Langenhove and Julie van der Zee and Christine van Broeckhoven},
  booktitle={Annals of medicine},
  year={2012}
}
There is increasing evidence that frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) represent a continuum of neurodegenerative diseases. FTLD is complicated by ALS in a significant proportion of patients, and neuropsychological studies have demonstrated frontotemporal dysfunction in up to 50% of ALS patients. More recently, advances in neuropathology and molecular genetics have started to disclose the biological basis for the observed clinical concurrence. TDP-43… CONTINUE READING

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