The molecular basis of sulfonylurea herbicide resistance in tobacco.

  title={The molecular basis of sulfonylurea herbicide resistance in tobacco.},
  author={Kwang Youl Lee and Jeffrey Townsend and James M. Tepperman and Margaret Black and C F Chui and Barbara J. Mazur and Pamela Dunsmuir and John R. Bedbrook},
  journal={The EMBO journal},
  volume={7 5},
The enzyme acetolactate synthase (ALS) is the target enzyme for the sulfonylurea and imidazolinone herbicides. We describe the isolation and characterization of the ALS genes from two herbicide-resistant mutants, C3 and S4-Hra, of Nicotiana tabacum. There are two distinct ALS genes in tobacco which are 0.7% divergent at the amino acid sequence level. The C3 mutant has a single Pro-Gln replacement at amino acid 196 in one ALS gene. This gene is termed the class I gene and is equivalent to the… CONTINUE READING


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