The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages.

@article{Chiocca1988TheMB,
  title={The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages.},
  author={E Antonio Chiocca and Peter Davies and Joseph P Stein},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 23},
  pages={11584-9}
}
Retinoic acid acts as an acute and specific inducer of tissue transglutaminase in mouse resident peritoneal macrophages. We have isolated cDNA clones for this enzyme and used them to demonstrate that this induction is due to the accumulation of tissue transglutaminase mRNA that occurs within minutes of exposure of macrophages to retinoic acid. The retinoic acid-induced increase in tissue transglutaminase mRNA is independent of concurrent protein synthesis and is due to an increased… CONTINUE READING

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