The molecular basis of phosphite and hypophosphite recognition by ABC-transporters

@inproceedings{Bisson2017TheMB,
  title={The molecular basis of phosphite and hypophosphite recognition by ABC-transporters},
  author={Claudine Bisson and Nathan B P Adams and Ben Stevenson and Amanda A Brindley and Despo Polyviou and Thomas S. Bibby and Patrick J Baker and C. Neil Hunter and Andrew Hitchcock},
  booktitle={Nature Communications},
  year={2017}
}
Inorganic phosphate is the major bioavailable form of the essential nutrient phosphorus. However, the concentration of phosphate in most natural habitats is low enough to limit microbial growth. Under phosphate-depleted conditions some bacteria utilise phosphite and hypophosphite as alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition from the environment is not fully understood. Here, we present crystal structures and ligand binding affinities of… CONTINUE READING
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