The molecular basis of phosphite and hypophosphite recognition by ABC-transporters

  title={The molecular basis of phosphite and hypophosphite recognition by ABC-transporters},
  author={C. Bisson and N. P. Adams and Ben Stevenson and A. Brindley and Despo Polyviou and T. Bibby and P. Baker and C. N. Hunter and A. Hitchcock},
  journal={Nature Communications},
  • C. Bisson, N. P. Adams, +6 authors A. Hitchcock
  • Published 2017
  • Medicine, Biology
  • Nature Communications
  • Inorganic phosphate is the major bioavailable form of the essential nutrient phosphorus. However, the concentration of phosphate in most natural habitats is low enough to limit microbial growth. Under phosphate-depleted conditions some bacteria utilise phosphite and hypophosphite as alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition from the environment is not fully understood. Here, we present crystal structures and ligand binding affinities of… CONTINUE READING

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