The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma.

@article{Binkley2004TheMB,
  title={The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma.},
  author={Charles E. Binkley and Lizhi Zhang and Joel K. Greenson and Thomas J. Giordano and Rork Kuick and Dave Misek and Samir M Hanash and Craig D. Logsdon and Diane M Simeone},
  journal={Pancreas},
  year={2004},
  volume={29 4},
  pages={254-63}
}
OBJECTIVES Tissue desmoplasia occurs in a number of disease states, but its molecular basis is poorly understood. To determine which genes are overexpressed in cells contained within the desmoplastic stroma of pancreatic adenocarcinoma and chronic pancreatitis, we undertook genetic profiling of microdissected tissue samples of pancreatic adenocarcinoma, chronic pancreatitis, normal pancreas, and pancreatic cancer cell lines. We observed that samples of both pancreatic adenocarcinoma and chronic… CONTINUE READING