The molecular basis of mouse sperm-zona pellucida binding: a still unresolved issue in developmental biology.


During murine fertilization, sperm bind to the specialized extracellular matrix of the egg, known as the zona pellucida (ZP). This matrix is composed of three major glycoproteins designated ZP1, ZP2, and ZP3. Three models for sperm-ZP binding are now under consideration. The domain-specific model posits that adhesion relies primarily on interactions between… (More)
DOI: 10.1530/REP-11-0118

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