The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization.

Abstract

The role of the mitochondrial protein frataxin in iron storage and detoxification, iron delivery to iron-sulfur cluster biosynthesis, heme biosynthesis, and aconitase repair has been extensively studied during the last decade. However, still no general consensus exists on the details of the mechanism of frataxin function and oligomerization. Here, using… (More)
DOI: 10.1074/jbc.M112.442285

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@article{Sderberg2013TheMB, title={The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization.}, author={Christopher A. G. S{\"{o}derberg and Sreekanth Rajan and Alexander V. Shkumatov and Oleksandr Gakh and Susanne Schaefer and Eva-Christina Ahlgren and Dmitri I. Svergun and Grazia Isaya and Salam Al-Karadaghi}, journal={The Journal of biological chemistry}, year={2013}, volume={288 12}, pages={8156-67} }