The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.

@article{Kuntz2009TheMB,
  title={The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.},
  author={Douglas Arthur Kuntz and Wei Zhong and Jun Guo and David Richard Rose and Marek Bar{\'a}th},
  journal={Chembiochem : a European journal of chemical biology},
  year={2009},
  volume={10 2},
  pages={
          268-77
        }
}
Mannostatin A is a potent inhibitor of the mannose-trimming enzyme, Golgi alpha-mannosidase II (GMII), which acts late in the N-glycan processing pathway. Inhibition of this enzyme provides a route to blocking the transformation-associated changes in cancer cell surface oligosaccharide structures. Here, we report on the synthesis of new Mannostatin derivatives and analyze their binding in the active site of Drosophila GMII by X-ray crystallography. The results indicate that the interaction with… CONTINUE READING
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