The molecular basis of acid insensitivity in the African naked mole-rat.

@article{Smith2011TheMB,
  title={The molecular basis of acid insensitivity in the African naked mole-rat.},
  author={Ewan St John Smith and Damir Omerba{\vs}i{\'c} and Stefan G. Lechner and Gireesh Anirudhan and Liudmila Lapatsina and Gary R Lewin},
  journal={Science},
  year={2011},
  volume={334 6062},
  pages={1557-60}
}
Acid evokes pain by exciting nociceptors; the acid sensors are proton-gated ion channels that depolarize neurons. The naked mole-rat (Heterocephalus glaber) is exceptional in its acid insensitivity, but acid sensors (acid-sensing ion channels and the transient receptor potential vanilloid-1 ion channel) in naked mole-rat nociceptors are similar to those in other vertebrates. Acid inhibition of voltage-gated sodium currents is more profound in naked mole-rat nociceptors than in mouse nociceptors… CONTINUE READING
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