The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.

Abstract

X-linked severe combined immunodeficiency is characterized by severe and persistent infections from early life resulting from profound impairment of both cellular and humoral immune function. XSCID is characterized by an absence or diminished number of T cells and histologic evidence of hypoplastic and abnormal differention of the thymic epithelium. The… (More)

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@article{Leonard1994TheMB, title={The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.}, author={W. J. Leonard and M. Noguchi and Stephen Russell and O W Mcbride}, journal={Immunological reviews}, year={1994}, volume={138}, pages={61-86} }