The molecular basis of JAK/STAT inhibition by SOCS1

  title={The molecular basis of JAK/STAT inhibition by SOCS1},
  author={Nicholas P.D. Liau and Artem Laktyushin and Isabelle S Lucet and James M Murphy and Shenggen Yao and Eden L. Whitlock and Kimberley Callaghan and Nicos A. Nicola and Nadia J. Kershaw and Jeffrey J Babon},
  booktitle={Nature Communications},
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of the family, can also inhibit JAK directly. Here we determine the structural basis of both these modes of inhibition. Due to alterations within the SOCS box domain, SOCS1 has a compromised ability to recruit Cullin5… CONTINUE READING
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