The molecular basis of CaMKII function in synaptic and behavioural memory

  title={The molecular basis of CaMKII function in synaptic and behavioural memory},
  author={J. Lisman and H. Schulman and H. Cline},
  journal={Nature Reviews Neuroscience},
  • J. Lisman, H. Schulman, H. Cline
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinase II (CaMKII) is necessary for LTP induction, is persistently activated by stimuli that elicit LTP, and can, by itself, enhance the efficacy of synaptic transmission. The analysis of CaMKII autophosphorylation and dephosphorylation indicates that this kinase could serve as a molecular switch that is… CONTINUE READING
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