The molecular basis of CaMKII function in synaptic and behavioural memory

@article{Lisman2002TheMB,
  title={The molecular basis of CaMKII function in synaptic and behavioural memory},
  author={J. Lisman and H. Schulman and H. Cline},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={175-190}
}
  • J. Lisman, H. Schulman, H. Cline
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Neuroscience
    • Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinase II (CaMKII) is necessary for LTP induction, is persistently activated by stimuli that elicit LTP, and can, by itself, enhance the efficacy of synaptic transmission. The analysis of CaMKII autophosphorylation and dephosphorylation indicates that this kinase could serve as a molecular switch that is… CONTINUE READING
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    References

    SHOWING 1-10 OF 144 REFERENCES
    α-CaMKII-dependent plasticity in the cortex is required for permanent memory
    • 387
    • PDF
    Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons.
    • 310
    Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II
    • 204
    • PDF
    An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory
    • 264
    • PDF
    The CaM kinase II hypothesis for the storage of synaptic memory
    • J. Lisman
    • Biology, Medicine
    • Trends in Neurosciences
    • 1994
    • 511
    The role of α-CaMKII autophosphorylation in neocortical experience-dependent plasticity
    • 80
    Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.
    • 1,162
    • PDF
    Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice.
    • 1,297
    CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
    • 535
    Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.
    • 1,403