The molecular basis of CaMKII function in synaptic and behavioural memory

John Lisman; Howard F Schulman; Hollis Cline

@article{Lisman2002TheMB, title={The molecular basis of CaMKII function in synaptic and behavioural memory}, author={John Lisman and Howard F Schulman and Hollis Cline}, journal={Nature Reviews Neuroscience}, year={2002}, volume={3}, pages={175-190} }

Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinase II (CaMKII) is necessary for LTP induction, is persistently activated by stimuli that elicit LTP, and can, by itself, enhance the efficacy of synaptic transmission. The analysis of CaMKII autophosphorylation and dephosphorylation indicates that this kinase could serve as a molecular switch that is… CONTINUE READING

J. L. Hanover, A. Taha, A. Silva, M. P. Stryker
Soc. Neurosci. Abstr
2001

The molecular basis of CaMKII function in synaptic and behavioural memory

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