The molecular basis for the specificity of fimE in the phase variation of type 1 fimbriae of Escherichia coli K-12.

@article{Kulasekara1999TheMB,
  title={The molecular basis for the specificity of fimE in the phase variation of type 1 fimbriae of Escherichia coli K-12.},
  author={Hemantha Don Kulasekara and Ian C. Blomfield},
  journal={Molecular microbiology},
  year={1999},
  volume={31 4},
  pages={1171-81}
}
The expression of type 1 fimbriae in Escherichia coli is phase variable, with cells switching between fimbriate (ON) and afimbriate (OFF) phases. The phase variation is dependent on the orientation of a 314 bp DNA element (the switch) that undergoes DNA inversion. DNA inversion requires either fimB or fimE, site-specific recombinases that differ in both specificity and activity. Whereas fimB promotes recombination with little orientational bias, fimE promotes recombination in the ON-to-OFF… CONTINUE READING

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