The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.

@article{Wang2007TheMB,
  title={The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.},
  author={Huanchen Wang and Howard Robinson and Hengming Ke},
  journal={Journal of molecular biology},
  year={2007},
  volume={371 2},
  pages={302-7}
}
Phosphodiesterases (PDEs) are key enzymes that control the cellular concentrations of the second messengers cAMP and cGMP. The mechanism for selective recognition of substrates cAMP and cGMP by individual PDE families remains a puzzle. To understand the mechanism for substrate recognition by PDE enzymes, the crystal structure of the catalytic domain of an inactive D201N mutant of PDE4D2 in complex with substrate cAMP has been determined at 1.56 A resolution. The structure shows that Gln369… CONTINUE READING