The molecular bases of cystinuria and lysinuric protein intolerance.

  title={The molecular bases of cystinuria and lysinuric protein intolerance.},
  author={Manuel Palac{\'i}n and Giuseppe Borsani and Gianfranco Sebastio},
  journal={Current opinion in genetics & development},
  volume={11 3},
Cystinuria and lysinuric protein intolerance are inherited aminoacidurias caused by defective amino-acid transport activities linked to a family of heteromeric amino-acid transporters (HATs). HATs comprise two subunits: co-expression of subunits 4F2hc and y(+)LAT-1 induces the efflux of dibasic amino acids from cells, whereas co-expression of subunits rBAT and b(o,+)AT induces the renal reabsorption and intestinal absorption of cystine and dibasic amino acids at the brush border of epithelial… CONTINUE READING


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