The molecular assembly and organization of signaling active B-cell receptor oligomers.

@article{Tolar2009TheMA,
  title={The molecular assembly and organization of signaling active B-cell receptor oligomers.},
  author={Pavel Tolar and Hae Won Sohn and Wanli Liu and Susan K Pierce},
  journal={Immunological reviews},
  year={2009},
  volume={232 1},
  pages={34-41}
}
In B cells, antigen drives the formation of B-cell receptor (BCR) clusters that initiate the formation of signaling complexes associated with the cytoplasmic domains of the BCRs. These signaling active complexes contain a number of protein and lipid kinases and phosphatases and adapter and scaffolding proteins that together function to trigger downstream signaling cascades leading to the activation of a variety of genes associated with B-cell activation. Although we are learning a considerable… CONTINUE READING