The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post‐Darwinian biology?

@article{Huang2012TheMA,
  title={The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post‐Darwinian biology?},
  author={Sui Huang},
  journal={BioEssays},
  year={2012},
  volume={34}
}
  • Sui Huang
  • Published 1 February 2012
  • Biology
  • BioEssays
The Neo‐Darwinian concept of natural selection is plausible when one assumes a straightforward causation of phenotype by genotype. However, such simple 1:1 mapping must now give place to the modern concepts of gene regulatory networks and gene expression noise. Both can, in the absence of genetic mutations, jointly generate a diversity of inheritable randomly occupied phenotypic states that could also serve as a substrate for natural selection. This form of epigenetic dynamics challenges Neo… 

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